Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition
Libé-Philippot B, Iwata R, Recupero AJ, Wierda K, Bernal Garcia S, Hammond L, van Benthem A, Limame R, Ditkowska M, Beckers S, Gaspariunaite V, Peze-Heidsieck E, Remans D, Charrier C, Theys T, Polleux F, Vanderhaeghen P.
Neuron 2024
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Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo
Virga DM, Hamilton S, Osei B, Morgan A, Kneis P, Zamponi E, Park NJ, Hewitt VL, Zhang D, Gonzalez KC, Russell FM, Grahame Hardie D, Prudent J, Bloss E, Losonczy A, Polleux F, Lewis TL Jr.
Nature Communications 2024
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Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development
Pilaz LJ, Liu J, Joshi K, Tsunekawa Y, Musso CM, D'Arcy BR, Suzuki IK, Alsina FC, Kc P, Sethi S, Vanderhaeghen P, Polleux F, Silver D.L.
Neuron 2023
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AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology
Tilokani L, Russell FM, Hamilton S, Virga DM, Segawa M, Paupe V, Gruszczyk AV, Protasoni M, Tabara LC, Johnson M, Anand H, Murphy MP, Hardie DG, Polleux F, Prudent
Science Advances 2022
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Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
Lee A, Kondapalli C, Virga DM, Lewis TL Jr, Koo SY, Ashok A, Mairet-Coello G, Herzig S, Foretz M, Viollet B, Shaw R, Sproul A, Polleux F
Nature Communications 2022
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Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42 toxicity
Hewitt VL, Miller-Fleming L, Twyning MJ, Andreazza S, Mattedi F, Prudent J, Polleux F, Vagnoni A, Whitworth AJ
Life Science Alliance 2022
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Compartment-specific tuning of dendritic feature selectivity by intracellular Ca2+ release
O'Hare JK, Gonzalez KC, Herrlinger SA, Hirabayashi Y, Hewitt VL, Blockus H, Szoboszlay M, Rolotti SV, Geiller TC, Negrean A, Chelur V, Polleux F, Losonczy A
Science 2022
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Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity
Turner NL, Macrina T, Bae JA, Yang R, Wilson AM, Schneider-Mizell C, Lee K, Lu R, Wu J, Bodor AL, Bleckert AA, Brittain D, Froudarakis E, Dorkenwald S, Collman F, Kemnitz N, Ih D, Silversmith WM, Zung J, Zlateski A, Tartavull I, Yu SC, Popovych S, Mu S, Wong W, Jordan CS, Castro M, Buchanan J, Bumbarger DJ, Takeno M, Torres R, Mahalingam G, Elabbady L, Li Y, Cobos E, Zhou P, Suckow S, Becker L, Paninski L, Polleux F, Reimer J, Tolias AS, Reid RC, da Costa NM, Seung HS
Cell 2022
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Local feedback inhibition tightly controls rapid formation of hippocampal place fields
Sebi V. Rolotti, Mohsin S. Ahmed, Miklos Szoboszlay, Tristan Geiller, Adrian Negrean, Heike Blockus, Kevin C. Gonzalez, Fraser T. Sparks, Ana Sofia Solis Canales,Anna L. Tuttman, Darcy S. Peterka, Boris V. Zemelman, Franck Polleux, Attila Losonczy
Neuron 2022
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Local circuit amplification of spatial selectivity in the hippocampus
Geiller T, Sadeh S, Rolotti SV, Blockus H, Vancura B, Negrean A, Murray AJ, Rózsa B, Polleux F, Clopath C, Losonczy A.
Nature 2021
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Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function
Blockus H, Rolotti SV, Szoboszlay M, Peze-Heidsieck E, Ming T, Schroeder A, Apostolo N, Vennekens KM, Katsamba PS, Bahna F, Mannepalli S, Ahlsen G, Honig B, Shapiro L, de Wit J, Losonczy A, Polleux F.
Cell Reports 2021
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A human-specific modifier of cortical connectivity and circuit function
Schmidt ERE, Zhao HT, Park JM, Dipoppa M, Monsalve-Mercado MM, Dahan JB, Rodgers CC, Lejeune A, Hillman EMC, Miller KD, Bruno RM, Polleux F.
Nature 2021
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Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed
Izadifar A, Courchet J, Virga DM, Verreet T, Hamilton S, Ayaz D, Misbaer A, Vandenbogaerde S, Monteiro L, Petrovic M, Sachse S, Yan B, Erfurth ML, Dascenco D, Kise Y, Yan J, Edwards-Faret G, Lewis T, Polleux F, Schmucker D
Neuron 2021
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Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation
Zehnder T, Petrelli F, Romanos J, De Oliveira Figueiredo EC, Lewis TL Jr, Déglon N, Polleux F, Santello M, Bezzi P
Cell Reports 2021
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Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking
Daniel Maxim Iascone, Yujie Li, Uygar Sumbul, ..., Idan Segev, Hanchuan Peng, Franck Polleux
Neuron 2020
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Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3
Bongjin Shin, Justine Kupferman, Ewoud Schmidt, Franck Polleux, Anne M Delany, and Sun-Kyeong Lee
Journal of Bone and Mineral Research 2019
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The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A- dependent synaptic development
Ewoud R. E. Schmidt, Justine V. Kupferman, Michelle Stackmann & Franck Polleux
Scientific Reports 2019
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Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body
José C Martínez, Lisa K Randolph, Daniel Maxim Iascone , Helena F Pernice, Franck Polleux, Ulrich Hengst
Neuron 2019
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Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment
Chunguang Ren, Qianying Yuan, Martha Braun, Xia Zhang, Björn Petri, Jiasheng Zhang, Dongjoo Kim, Julia Guez-Haddad, Wenzhi Xue, Weijun Pan, Rong Fan, Paul Kubes, Zhaoxia Sun, Yarden Opatowsky, Franck Polleux, Erdem Karatekin, Wenwen Tang, Dianqing Wu
Developmental cell 2019
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MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
Tommy L. Lewis, Jr, Seok-Kyu Kwon, Annie Lee, Reuben Shaw, and Franck Polleux
Nature Communications 2018
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Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
Virginie Courchet, Amanda J. Roberts, Géraldine Meyer-Dilhet, Peggy Del Carmine, Tommy L. Lewis Jr, Franck Polleux & Julien Courchet
Nature Communications 2018
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Correlated Light-Serial Scanning Electron Microscopy (CoLSSEM) for ultrastructural visualization of single neurons in vivo
Yusuke Hirabayashi, Juan Carlos Tapia, Franck Polleux
Scientific Reports 2018
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ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons
Yusuke Hirabayashi, Seok-Kyu Kwon, Hunki Paek, Wolfgang M. Pernice, Maëla A. Paul, Jinoh Lee, Parsa Erfani, Ashleigh Raczkowski, Donald S. Petrey, Liza A. Pon, Franck Polleux
Science 2017
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Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly
George Mountoufaris, Weisheng V. Chen, Yusuke Hirabayashi, Sean O’Keeffe, Maxime Chevee, Chiamaka L. Nwakeze, Franck Polleux, Tom Maniatis
Science 2017
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Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo
Tommy L Lewis Jr, Gergely F Turi, Seok-Kyu Kwon, Attila Losonczy, Franck Polleux
Current Biology 2016
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SRGAP2 and its human-specific paralog co-regulate the development of excitatory and inhibitory synapses
Matteo Fossati, Rocco Pizzarelli, Ewoud R. Schmidt, Justine V. Kupferman, David Stroebel, Franck Polleux, Cécile Charrier
Neuron 2016
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LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons
Seok-Kyu Kwon, Richard Sando 3rd, Tommy L Lewis, Yusuke Hirabayashi, Anton Maximov, Franck Polleux
PLoS Biology 2016
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SNAREs controlling vesicular release of BDNF and development of callosal axons
Masafumi Shimojo, Julien Courchet, Simon Pieraut, Nina Torabi-Rander, Richard Sando, III, Franck Polleux, Anton Maximov
Cell Reports 2015
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Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture
Julien Courchet, Tommy Lewis, Jr., Sohyon Lee, Virginie Courchet, Deng-Yuan Liou, Shinichi Aizawa, Franck Polleux
Cell 2013
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The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Ab Oligomers through Tau Phosphorylation
Georges Mairet-Coello, Julien Courchet, Simon Pieraut, Virginie Courchet, Anton Maximov, Franck Polleux
Neuron 2013
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The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently
Jaeda Coutinho-Budd, Vladimir Ghukasyan, Mark J. Zylka, and Franck Polleux
Journal of Cell Science 2012
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Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation
Cécile Charrier, Kaumudi Joshi, Jaeda Coutinho-Budd, Ji-Eun Kim, Nelle Lambert, Jacqueline de Marchena, Wei-Lin Jin, Pierre Vanderhaeghen, Anirvan Ghosh, Takayuki Sassa, Franck Polleux
Cell 2012
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AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress
Tyisha Williams, Julien Courchet, Benoit Viollet, Jay E. Brenman and Franck Polleux
PNAS 2011
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The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis
Sabrice Guerrier, Jaeda Coutinho-Budd, Takayuki Sassa, Aurélie Gresset, Nicole Vincent Jordan, Keng Chen, Wei-Lin Jin, Adam Frost, Franck Polleux
Cell 2009
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KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent
Manner Dante Bortone and Franck Polleux
Neuron 2009
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Topography of Thalamic Projections Requires Attractive and Repulsive Functions of Netrin-1 in the Ventral Telencephalon
Ashton W Powell, Takayuki Sassa, Yongqin Wu, Marc Tessier-Lavigne, Franck Polleux
PLoS Biology 2008
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LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
Anthony P Barnes, Brendan N Lilley, Y Albert Pan, Lisa J Plummer, Ashton W Powell, Alexander N Raines, Joshua R Sanes, Franck Polleux
Cell 2007
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